公开(公告)号：US09662425B2

公开(公告)日：2017-05-30

申请号：US14786060

申请日：2014-04-22

申请人： Stryker European Holdings I, LLC

发明人： Mirjam Lilja ,  Jan Henrik Sörensen ,  Philip Procter ,  Hartwig Steckel ,  Torben Christian Sörensen

IPC分类号： A61L27/32 ,  A61L31/16 ,  A61C8/00 ,  A61L27/54 ,  A61L31/08 ,  A61C19/06 ,  C23C4/12

CPC分类号： A61L31/16 ,  A61C8/0013 ,  A61C19/063 ,  A61L27/32 ,  A61L27/54 ,  A61L31/086 ,  C23C4/134

摘要： A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60° C. to about 100° C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.