Invention Grant
- Patent Title: Universal sample preparation system and use in an integrated analysis system
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Application No.: US14552389Application Date: 2014-11-24
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Publication No.: US09663819B2Publication Date: 2017-05-30
- Inventor: Stevan B. Jovanovich , William D. Nielsen , Mattias Vangbo , Ezra Van Gelder , Omar El-Sissi
- Applicant: IntegenX Inc.
- Applicant Address: US CA Pleasanton
- Assignee: INTEGENX INC.
- Current Assignee: INTEGENX INC.
- Current Assignee Address: US CA Pleasanton
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: G01N1/10
- IPC: G01N1/10 ; G01N33/00 ; C12Q1/68 ; G01N35/00 ; G01N1/31 ; G01N27/74 ; G01N21/64 ; G01N27/447 ; G01N1/40 ; G01J3/44

Abstract:
The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
Public/Granted literature
- US20150136602A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM Public/Granted day:2015-05-21
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