Embodiments of a color filter array include a plurality of tiled minimal repeating units, each minimal repeating unit comprising an M×N set of individual filters, and each individual filter in the set having a photoresponse selected from among four different photoresponses. Each minimal repeating unit includes a checkerboard pattern of filters of the first photoresponse, and filters of the second, third, and fourth photoresponses distributed among the checkerboard pattern such that the filters of the second, third, and fourth photoresponses are sequentially symmetric about one or both of a pair of orthogonal axes of the minimal repeating unit.