A vehicle includes two or more wheel assemblies, each having a wheel assembly sensor. Each of the wheel assembly sensors is configured to produce acceleration data and pressure data associated with its associated wheel assembly. A wheel assembly tampering module communicatively coupled to the plurality of wheel assembly sensors is configured to produce an output indicative of wheel assembly tampering based on at the acceleration data and the pressure data. Inclination data and signal strength data (associated with each of the wheel assembly sensors) may also be used to determine wheel assembly tampering.