Invention Grant
- Patent Title: Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
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Application No.: US14361802Application Date: 2012-11-30
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Publication No.: US09675675B2Publication Date: 2017-06-13
- Inventor: Ying Zhang , Percy T. Fenn , Peter R. Johnson
- Applicant: 3M INNOVATIVE PROPERTIES COMPANY
- Applicant Address: US MN St. Paul
- Assignee: 3M Innovative Properties Company
- Current Assignee: 3M Innovative Properties Company
- Current Assignee Address: US MN St. Paul
- International Application: PCT/US2012/067278 WO 20121130
- International Announcement: WO2013/082418 WO 20130606
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61M5/24 ; A61K38/29 ; A61K9/00 ; A61M37/00 ; A61K31/4172 ; A61K47/18 ; A61K38/23 ; A61K38/28 ; A61K38/47 ; A61K31/198 ; A61L31/10 ; A61L31/16 ; A61K38/22 ; A61K47/22

Abstract:
A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
Public/Granted literature
Information query
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