公开(公告)号：US10695289B2

公开(公告)日：2020-06-30

申请号：US15766469

申请日：2016-10-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kenneth E. Brown ,  Daniel M. Dohmeier ,  Joan T. Moseman ,  Ying Zhang ,  Alan Harris ,  Gary Hattersley ,  Lisa A. Dick

IPC: A61K9/00 ,  A61K47/02 ,  A61K38/00 ,  A61B17/20 ,  A61B17/00

Abstract: A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.

公开(公告)号：US10568937B2

公开(公告)日：2020-02-25

申请号：US16092587

申请日：2017-04-06

Applicant: Radius Health, Inc. ,  3M Innovative Properties Company

Inventor： Gary Hattersley ,  Alan Harris ,  Jamal Saeh ,  Ehab Hamed ,  Kenneth Brown ,  Daniel Dohmeier ,  Joan Moseman ,  Ying Zhang ,  Lisa Dick

IPC: A61K38/29 ,  A61K9/70 ,  A61P19/02 ,  A61P19/10 ,  A61K9/00 ,  A61K33/06 ,  A61K33/30 ,  A61K47/10

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

公开(公告)号：US09675675B2

公开(公告)日：2017-06-13

申请号：US14361802

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K38/00 ,  A61M5/24 ,  A61K38/29 ,  A61K9/00 ,  A61M37/00 ,  A61K31/4172 ,  A61K47/18 ,  A61K38/23 ,  A61K38/28 ,  A61K38/47 ,  A61K31/198 ,  A61L31/10 ,  A61L31/16 ,  A61K38/22 ,  A61K47/22

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

公开(公告)号：US20230144048A1

公开(公告)日：2023-05-11

申请号：US17913495

申请日：2021-03-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Lin Chen ,  Stefan H. Gryska ,  Dong-Wei Zhu ,  Bret W. Ludwig ,  Matthew J. Bongers ,  Ying Zhang

IPC: C09J133/10 ,  C09J7/35 ,  C09J11/06

CPC classification number: C09J133/10 ,  C09J7/35 ,  C09J11/06 ,  C09J2433/00

Abstract: Crosslinked (meth)acrylate-based pressure sensitive adhesives are capable of attachment to mammalian skin for at least 10 days. The crosslinked adhesive composition includes a crosslinked (meth)acrylate-based copolymer free from polar groups, and a hydrogenated hydrocarbon tackifier resin. The crosslinked adhesive composition is prepared by photocrosslinking a hot melt processable blend of a (meth)acrylate copolymer and a hydrogenated hydrocarbon tackifier resin. The (meth)acrylate copolymer is the reaction product of an alkyl (meth)acrylate monomer with alkyl groups of 4-22 carbon atoms and are free of polar groups, and a copolymerizable photocrosslinker.

公开(公告)号：US20220213358A1

公开(公告)日：2022-07-07

申请号：US17603604

申请日：2020-05-19

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Vasav Sahni ,  Jason D. Clapper ,  John W. McAllister ,  Albert I. Everaerts ,  Jacob P. Johnson ,  Zhong Chen ,  Ying Zhang ,  Benjamin J. Bending

IPC: C09J123/22 ,  C08K5/01 ,  C08F220/18 ,  C08F222/10 ,  C08K5/3412

Abstract: An adhesive composition is described comprising a polyisobutylene polymer component; and up to 30 wt.-% of at least one aliphatic multifunctional component comprising at least two ethylenically unsaturated groups selected from (meth)acryl or vinyl ether. The monomer comprises a hydrocarbon moiety with greater than 12 contiguous carbon atoms. When the hydrocarbon moiety is branched, the hydrocarbon moiety comprises side chains with at least two carbon atoms. The aliphatic multifunctional component is sufficiently compatible such that crosslinked adhesive composition at a thickness of 20 microns has a haze of less than 3%. Also described are adhesive articles.

公开(公告)号：US20210292458A1

公开(公告)日：2021-09-23

申请号：US17258231

申请日：2019-07-08

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Vasav Sahni ,  Saswata Chakraborty ,  Wayne S. Mahoney ,  Jason D. Clapper ,  Jacob P. Johnson ,  Ying Zhang ,  Albert I. Everaerts ,  Bryan V. Hunt ,  Richard B. Ross

IPC: C08F255/10 ,  C08L23/22 ,  C09J123/22 ,  C09J153/02

Abstract: A composition is described comprising a styrene-isobutylene block copolymer; and at least one ethylenically unsaturated monomer. After curing the composition comprises polymerized units of the ethylenically unsaturated monomer. In some embodiments the ethylenically unsaturated groups are selected from (meth)acryl or vinyl ether. The composition is suitable for use as a (e.g. pressure sensitive) adhesive. Articles, methods of making an article, and methods of bonding are also described.

公开(公告)号：US20210189192A1

公开(公告)日：2021-06-24

申请号：US16483546

申请日：2018-03-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Vasav Sahni ,  Jason D. Clapper ,  Jacob P. Johnson ,  Ying Zhang

IPC: C09J7/38 ,  C09J11/06

Abstract: In one embodiment, an adhesive composition is described comprising a polyisobutylene polymer component, a styrene-isobutylene block copolymer, and optionally a tackifier. The polyisobutylene polymer component comprises one or more polyisobutylene polymers. The polyisobutylene polymer component has an average weight average molecular weight ranging from 100 g/mole to less than 15,000 g/mole. In some embodiments, the adhesive composition is a pressure sensitive adhesive.

公开(公告)号：US20200164045A1

公开(公告)日：2020-05-28

申请号：US16733779

申请日：2020-01-03

Applicant: Radius Health, Inc. ,  3M Innovative Properties Company

Inventor： Gary Hattersley ,  Alan Harris ,  Jamal Saeh ,  Ehab Hamed ,  Kenneth Brown ,  Daniel Dohmeier ,  Joan Moseman ,  Ying Zhang ,  Lisa Dick

IPC: A61K38/29 ,  A61K47/10 ,  A61K33/30 ,  A61K33/06 ,  A61K9/00 ,  A61P19/10 ,  A61P19/02 ,  A61K9/70

Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

公开(公告)号：US20190290738A1

公开(公告)日：2019-09-26

申请号：US16279770

申请日：2019-02-19

Applicant: Radius Health, Inc. ,  3M Innovative Properties Company, a wholly owned subsidiary of 3M Company

Inventor： Gary Hattersley ,  Kris J. Hansen ,  Amy S. Determan ,  Ying Zhang

IPC: A61K38/29 ,  A61M37/00 ,  A61K9/00 ,  A61K9/20

Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.

公开(公告)号：US20180344631A1

公开(公告)日：2018-12-06

申请号：US16059522

申请日：2018-08-09

Applicant: 3M Innovative Properties Company

Inventor： Ying Zhang ,  Kristen J. Hansen ,  Amy S. Determan

IPC: A61K9/00 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.