公开(公告)号：US20140330198A1

公开(公告)日：2014-11-06

申请号：US14361802

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K47/22 ,  A61K47/18 ,  A61M37/00 ,  A61K38/28 ,  A61K38/47 ,  A61K38/29 ,  A61K38/22

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

Abstract translation: 公开了一种包括微针阵列和设置在微针上或其内的涂层的医疗装置和制造这种装置的方法。 该涂层包括肽治疗剂和氨基酸。 还公开了在微针阵列上用氨基酸稳定肽治疗剂的方法。 在一些情况下，肽治疗剂和氨基酸都具有净正电荷或两者具有净负电荷。 在一些情况下，肽治疗剂是组氨酸。

公开(公告)号：US09675675B2

公开(公告)日：2017-06-13

申请号：US14361802

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K38/00 ,  A61M5/24 ,  A61K38/29 ,  A61K9/00 ,  A61M37/00 ,  A61K31/4172 ,  A61K47/18 ,  A61K38/23 ,  A61K38/28 ,  A61K38/47 ,  A61K31/198 ,  A61L31/10 ,  A61L31/16 ,  A61K38/22 ,  A61K47/22

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

公开(公告)号：US20200147209A1

公开(公告)日：2020-05-14

申请号：US16744247

申请日：2020-01-16

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Peter R. Johnson

IPC: A61K39/39 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61K39/00 ,  A61K47/38 ,  A61K47/26 ,  A61K47/02 ,  A61K9/06 ,  A61K9/00

Abstract: Compositions for coating microneedles with aluminum-adjuvanted vaccines are provided comprising an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension; a vaccine in an amount effective to stimulate an immune response in a mammal; a sugar, sugar alcohol, or combinations thereof; and a thickener. Some embodiments of the compositions have a viscosity of 500 to 30,000 cps when measured at 100 s−1 and temperature of 25° C. Microneedle devices coated with the compositions, as well as methods of forming the compositions and coating the microneedles, and methods of maximizing the aluminum content of vaccine-coated microneedle arrays are also provided.

公开(公告)号：US10154957B2

公开(公告)日：2018-12-18

申请号：US15480813

申请日：2017-04-06

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K38/29 ,  A61M37/00 ,  A61K9/00 ,  A61K31/4172 ,  A61K47/18 ,  A61K38/23 ,  A61K38/28 ,  A61K38/47 ,  A61K31/198 ,  A61L31/10 ,  A61L31/16 ,  A61K38/22 ,  A61K47/22

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

公开(公告)号：US20170209367A1

公开(公告)日：2017-07-27

申请号：US15480813

申请日：2017-04-06

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K9/00 ,  A61K47/18 ,  A61M37/00 ,  A61K38/28 ,  A61K38/47 ,  A61K38/29 ,  A61K38/23

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

公开(公告)号：US09623087B2

公开(公告)日：2017-04-18

申请号：US14361787

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K38/29 ,  A61M37/00 ,  A61K9/00 ,  A61K31/4172 ,  A61K47/18 ,  A61K38/23 ,  A61K38/28 ,  A61K38/47 ,  A61K31/198 ,  A61L31/10 ,  A61L31/16 ,  A61K38/22 ,  A61K47/22

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

公开(公告)号：US20140343499A1

公开(公告)日：2014-11-20

申请号：US14361787

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Ying Zhang ,  Percy T. Fenn ,  Peter R. Johnson

IPC: A61K38/29 ,  A61K9/00 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

Abstract translation: 公开了一种包括微针阵列和设置在微针上或其内的涂层的医疗装置和制造这种装置的方法。 该涂层包括肽治疗剂和氨基酸。 还公开了在微针阵列上用氨基酸稳定肽治疗剂的方法。 在一些情况下，肽治疗剂和氨基酸都具有净正电荷或两者具有净负电荷。 在一些情况下，肽治疗剂是组氨酸。