Invention Grant
- Patent Title: Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
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Application No.: US15351955Application Date: 2016-11-15
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Publication No.: US09676775B2Publication Date: 2017-06-13
- Inventor: Ivar M. McDonald , Naidu S. Chowdari , Walter Lewis Johnson , Yong Zhang , Robert M. Borzilleri , Sanjeev Gangwar
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; C07D471/04
Abstract:
Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Public/Granted literature
- US20170057959A1 HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING Public/Granted day:2017-03-02
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