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公开(公告)号:US11447775B2
公开(公告)日:2022-09-20
申请号:US16961624
申请日:2019-01-11
发明人: Richard E. Olson , Angela M. Cacace , Jere E. Meredith, Jr. , Nino Devidze , James K. Loy , Carl J. Baldick , Annapurna Pendri , Ivar M. McDonald , Peter Hagedorn , Marianne Lerbech Jensen
IPC分类号: C07H21/04 , C12N15/113
摘要: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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公开(公告)号:US10954238B1
公开(公告)日:2021-03-23
申请号:US16843024
申请日:2020-04-08
发明人: Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号: C07D403/04 , C07D487/04 , A61K31/196 , C07D471/04
摘要: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号:US20190275148A1
公开(公告)日:2019-09-12
申请号:US16282138
申请日:2019-02-21
发明人: Richard E. Olson , Brian R. Anderson , Peter Hagedorn , Marianne Lerbech Jensen , Ivar M. McDonald , Stephen E. Mercer
IPC分类号: A61K39/395 , C12N5/077 , C12N15/113 , C12N5/074 , A61K47/60 , A61K47/64 , A61K47/54 , A61P9/04 , A61P9/12 , A61K9/00
摘要: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.
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公开(公告)号:US09796713B2
公开(公告)日:2017-10-24
申请号:US15317553
申请日:2015-06-05
IPC分类号: C07D471/18 , C07D519/00
CPC分类号: C07D471/18 , C07D519/00
摘要: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号:US20160101104A1
公开(公告)日:2016-04-14
申请号:US14974248
申请日:2015-12-18
发明人: James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. lwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号: A61K31/506
CPC分类号: A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号:US20220324859A1
公开(公告)日:2022-10-13
申请号:US17164009
申请日:2021-02-01
发明人: Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号: C07D471/04
摘要: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号:US11058767B2
公开(公告)日:2021-07-13
申请号:US16282138
申请日:2019-02-21
发明人: Richard E. Olson , Brian R. Anderson , Peter Hagedorn , Marianne Lerbech Jensen , Ivar M. McDonald , Stephen E. Mercer
IPC分类号: C07H21/02 , C07H21/04 , A61K39/395 , A61K47/54 , A61K47/64 , A61K47/60 , A61P9/12 , A61P9/04 , A61K9/00 , C12N5/074 , C12N5/077 , C12N15/113 , A61K31/713 , A61K39/00
摘要: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.
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公开(公告)号:US09822144B2
公开(公告)日:2017-11-21
申请号:US15587715
申请日:2017-05-05
发明人: Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号: C07D487/04 , C07D519/00 , C07K5/062
CPC分类号: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号:US09708323B2
公开(公告)日:2017-07-18
申请号:US15317546
申请日:2015-06-05
IPC分类号: C07D471/18
CPC分类号: C07D471/18
摘要: The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号:US10669272B2
公开(公告)日:2020-06-02
申请号:US16452679
申请日:2019-06-26
发明人: Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC分类号: C07D403/04 , C07D487/04 , C07D471/04
摘要: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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