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公开(公告)号：US20230193260A1
公开(公告)日：2023-06-22
申请号：US17815493
申请日：2022-07-27
Inventor： Richard E. OLSON , Angela M. Cacace , Jere E. Meredith, JR. , Nino Devidze , James K. Loy , Carl J. Baldick , Annapurna Pendri , Ivar M. McDonald , Peter Hagedorn , Marianne Lerbech Jensen
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/351 , C12N2310/3231
Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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公开(公告)号：US11447775B2
公开(公告)日：2022-09-20
申请号：US16961624
申请日：2019-01-11
Inventor： Richard E. Olson , Angela M. Cacace , Jere E. Meredith, Jr. , Nino Devidze , James K. Loy , Carl J. Baldick , Annapurna Pendri , Ivar M. McDonald , Peter Hagedorn , Marianne Lerbech Jensen
IPC: C07H21/04 , C12N15/113
Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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公开(公告)号：US10954238B1
公开(公告)日：2021-03-23
申请号：US16843024
申请日：2020-04-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D487/04 , A61K31/196 , C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20190275148A1
公开(公告)日：2019-09-12
申请号：US16282138
申请日：2019-02-21
Inventor： Richard E. Olson , Brian R. Anderson , Peter Hagedorn , Marianne Lerbech Jensen , Ivar M. McDonald , Stephen E. Mercer
IPC: A61K39/395 , C12N5/077 , C12N15/113 , C12N5/074 , A61K47/60 , A61K47/64 , A61K47/54 , A61P9/04 , A61P9/12 , A61K9/00
Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.
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公开(公告)号：US09796713B2
公开(公告)日：2017-10-24
申请号：US15317553
申请日：2015-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. McDonald , Richard E. Olson , Robert A. Mate
IPC: C07D471/18 , C07D519/00
CPC classification number: C07D471/18 , C07D519/00
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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Patent Agency Ranking
公开(公告)号：US20160101104A1
公开(公告)日：2016-04-14
申请号：US14974248
申请日：2015-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. lwuagwu , F. Christopher Zusi , John E. Macor
IPC: A61K31/506
CPC classification number: A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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公开(公告)号：US10669272B2
公开(公告)日：2020-06-02
申请号：US16452679
申请日：2019-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D403/04 , C07D487/04 , C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20200109140A1
公开(公告)日：2020-04-09
申请号：US16452679
申请日：2019-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender VELAPARTHI , Louis S. Chupak , Chetan Padmakar Darne , Min Ding , Robert G. Gentles , Yazhong Huang , Manjunatha Narayana Rao Kamble , Scott W. Martin , Raju Mannoori , Ivar M. McDonald , Richard E. Olson , Hasibur Rahaman , Prasada Rao Jalagam , Saumya Roy , Gopikishan Tonukunuru , Sivasudar Velaiah , Jayakumar Sankara Warrier , Xiaofan Zheng , John S. Tokarski , Bireshwar Dasgupta , Kotha Rathnakar Reddy , Thiruvenkadam Raja
IPC: C07D471/04
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US10112975B2
公开(公告)日：2018-10-30
申请号：US15785675
申请日：2017-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC: C07D487/04 , C07D519/00 , C07K5/062
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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10.发明申请QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开喹啉化合物作为ALPHA-7非丁醇乙酰胆碱受体配体公开(公告)号：US20150094309A1
公开(公告)日：2015-04-02
申请号：US14574653
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC: C07D519/00
CPC classification number: A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
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