A driver circuit drives data to an output based on an input data signal in a transmission mode. The driver circuit includes transistors. A comparator generates a comparison output in a calibration mode based on a reference signal and a signal at the output of the driver circuit. A calibration control circuit adjusts an equivalent resistance of the transistors in the driver circuit based on the comparison output in the calibration mode. The equivalent resistance of the transistors in the driver circuit can be adjusted to support the transmission of data according to multiple different data transmission protocols using transmission links having different characteristic impedances. The equivalent resistance of the transistors in the driver circuit can also be adjusted to compensate for resistance in the package routing conductors and/or to compensate for parasitic resistance.