- 专利标题: Designer osteogenic proteins
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申请号: US14589468申请日: 2015-01-05
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公开(公告)号: US09688735B2公开(公告)日: 2017-06-27
- 发明人: Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
- 申请人: Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
- 申请人地址: US NJ Madison
- 专利权人: Wyeth LLC
- 当前专利权人: Wyeth LLC
- 当前专利权人地址: US NJ Madison
- 主分类号: C07K14/51
- IPC分类号: C07K14/51 ; C12N15/12
摘要:
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
公开/授权文献
- US20160207973A1 DESIGNER OSTEOGENIC PROTEINS 公开/授权日:2016-07-21