公开(公告)号：US20160207973A1

公开(公告)日：2016-07-21

申请号：US14589468

申请日：2015-01-05

申请人： Stephen BERASI ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

发明人： Stephen BERASI ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： C07K14/51

CPC分类号： C07K14/51

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其用途的方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。

公开(公告)号：US09688735B2

公开(公告)日：2017-06-27

申请号：US14589468

申请日：2015-01-05

申请人： Stephen Berasi ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

发明人： Stephen Berasi ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： C07K14/51 ,  C12N15/12

CPC分类号： C07K14/51

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.