Invention Grant
- Patent Title: Targeting c-Rel O-GlcNAcylation and uses thereof
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Application No.: US14166681Application Date: 2014-01-28
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Publication No.: US09696296B2Publication Date: 2017-07-04
- Inventor: Parameswaran Ramakrishnan , David Baltimore
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A61K31/00
- IPC: A61K31/00 ; G01N33/50 ; A61K31/513 ; A61K31/655 ; A61K31/7028
Abstract:
Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.
Public/Granted literature
- US20140212876A1 TARGETING C-REL O-GLCNACYLATION AND USES THEREOF Public/Granted day:2014-07-31
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