公开(公告)号：US09696296B2

公开(公告)日：2017-07-04

申请号：US14166681

申请日：2014-01-28

Applicant: California Institute of Technology

Inventor： Parameswaran Ramakrishnan ,  David Baltimore

IPC: A61K31/00 ,  G01N33/50 ,  A61K31/513 ,  A61K31/655 ,  A61K31/7028

CPC classification number: G01N33/5023 ,  A61K31/513 ,  A61K31/655 ,  A61K31/7028 ,  G01N2440/38

Abstract: Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

公开(公告)号：US20140212876A1

公开(公告)日：2014-07-31

申请号：US14166681

申请日：2014-01-28

Applicant: California Institute of Technology

Inventor： Parameswaran Ramakrishnan ,  David Baltimore

IPC: G01N33/50

CPC classification number: G01N33/5023 ,  A61K31/513 ,  A61K31/655 ,  A61K31/7028 ,  G01N2440/38

Abstract: Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

Abstract translation: 丝氨酸350已经被鉴定为c-Rel的O-糖基化的位点。 提供了用于鉴定能够阻断c-Rel活化的组合物的方法。 所述方法通常涉及鉴定在丝氨酸350残基处抑制c-Rel的O-GlcNAc化的化合物，从而防止c-Rel活化并产生c-Rel依赖性细胞因子。