Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
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Application No.: US14008388Application Date: 2012-03-20
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Publication No.: US09718854B2Publication Date: 2017-08-01
- Inventor: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
- Applicant: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
- Applicant Address: CA Burnaby US NJ Rahway
- Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CA Burnaby US NJ Rahway
- Agency: Clark & Elbing LLP
- Priority: WOPCT/CN2011/072330 20110331
- International Application: PCT/CA2012/000267 WO 20120320
- International Announcement: WO2012/129651 WO 20121004
- Main IPC: C07H19/24
- IPC: C07H19/24 ; C07D513/04 ; A61K31/429 ; C12N9/99 ; C12Q1/34 ; C07H9/06 ; C07H11/00 ; C07H13/12 ; C07H15/04 ; C07H15/12 ; C07H15/18 ; C07H15/203 ; C07H15/207 ; C07H17/02 ; C07H17/04 ; A61K31/7056
Abstract:
The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
Public/Granted literature
- US20140088028A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2014-03-27
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