发明授权
- 专利标题: Chelate-controlled diastereoselective hydrogenation with heterogeneous catalyst
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申请号: US15302936申请日: 2015-09-28
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公开(公告)号: US09751848B2公开(公告)日: 2017-09-05
- 发明人: David Dunn , Howard Winston Tyrrell Sutton , John Ing Chuan Daly , Simon Jonathon Grant , Lian Hutchings , Patrice Georges Antonin Ribiere , Matthew Richard Gibbings , Sergio Aaron Gamboa Martinez , Craig Anderson , Yulia Rogan
- 申请人: THOMAS SWAN & CO. LTD
- 申请人地址: GB Durham
- 专利权人: Thomas Swan & Co. Ltd
- 当前专利权人: Thomas Swan & Co. Ltd
- 当前专利权人地址: GB Durham
- 代理机构: Knobbe Martens Olson & Bear LLP
- 优先权: GB1417035.1 20140926
- 国际申请: PCT/GB2015/052802 WO 20150928
- 国际公布: WO2016/046575 WO 20160331
- 主分类号: C07D315/00
- IPC分类号: C07D315/00 ; C07D307/12 ; B01J23/58
摘要:
A catalyst, method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst.This equation, using the preferred substrate, best illustrates the invention: