Invention Grant
- Patent Title: Cyclopropanamine compound and use thereof
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Application No.: US14435085Application Date: 2013-10-11
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Publication No.: US09751885B2Publication Date: 2017-09-05
- Inventor: Naoki Tomita , Daisuke Tomita , Yusuke Tominari , Shinichi Imamura , Shinji Morimoto , Takuto Kojima , Masashi Toyofuku , Yasushi Hattori , Tomohiro Kaku , Mitsuhiro Ito
- Applicant: Takeda Pharmaceutical Company Limited
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2012-227243 20121012; JP2013-022534 20130207
- International Application: PCT/JP2013/077863 WO 20131011
- International Announcement: WO2014/058071 WO 20140417
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07C255/58 ; C07C255/60 ; C07D231/40 ; C07C317/40 ; C07C237/30 ; C07C237/38 ; C07C237/40 ; C07C255/29 ; A61K45/06 ; C07D309/14 ; C07D319/18 ; C07D413/12 ; C07D241/12 ; C07D417/12 ; C07D261/14 ; C07D207/12 ; C07D285/135 ; C07D211/58 ; C07D295/135 ; C07D213/40 ; C07D207/46 ; C07D213/36 ; C07D223/12 ; C07D231/38 ; C07D241/18 ; C07D265/36 ; C07D277/38 ; C07D333/20 ; C07D405/12 ; C07D471/04 ; C07D513/04

Abstract:
The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.
Public/Granted literature
- US20150266881A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF Public/Granted day:2015-09-24
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