Invention Grant
- Patent Title: Differentiation of human pluripotent stem cells
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Application No.: US14963436Application Date: 2015-12-09
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Publication No.: US09752126B2Publication Date: 2017-09-05
- Inventor: Alireza Rezania , Benjamin Fryer
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agent Lois A. Gianneschi
- Main IPC: C12N5/071
- IPC: C12N5/071
Abstract:
The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.
Public/Granted literature
- US20160160182A1 Differentiation of Human Pluripotent Stem Cells Public/Granted day:2016-06-09
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