Invention Grant
- Patent Title: Targeting of EWS-FLI1 as anti-tumor therapy
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Application No.: US14696005Application Date: 2015-04-24
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Publication No.: US09758481B2Publication Date: 2017-09-12
- Inventor: Jeffrey A. Toretsky , Aykut Uren , Milton Lang Brown , Yali Kong
- Applicant: Georgetown University
- Applicant Address: US DC Washington
- Assignee: GEORGETOWN UNIVERSITY
- Current Assignee: GEORGETOWN UNIVERSITY
- Current Assignee Address: US DC Washington
- Agency: Knobbe, Martens, Olson & Bear LLP
- Main IPC: C07D209/38
- IPC: C07D209/38 ; A61K31/404 ; C07D401/06 ; A61K38/00 ; C07K7/08 ; C07K7/06 ; A61K45/06
Abstract:
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
Public/Granted literature
- US20150329488A1 TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY Public/Granted day:2015-11-19
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