公开(公告)号：US20170157089A1

公开(公告)日：2017-06-08

申请号：US15365794

申请日：2016-11-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/404 ,  A61K47/40 ,  A61K45/06

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

公开(公告)号：US09522908B2

公开(公告)日：2016-12-20

申请号：US14047362

申请日：2013-10-07

Applicant: Georgetown University

Inventor： Milton L. Brown ,  Mikell Paige ,  Jeffrey A. Torestsky ,  Aykut Uren ,  George Kosturko ,  Gullay Bulut

IPC: C07D215/38 ,  A61K31/535 ,  A61K31/47 ,  C07D413/12 ,  C07D209/48 ,  C07D215/24 ,  C07D217/24 ,  C07D401/12 ,  C07D471/04 ,  C07D237/30 ,  C07D401/06

CPC classification number: C07D413/12 ,  C07D209/48 ,  C07D215/24 ,  C07D215/38 ,  C07D217/24 ,  C07D237/30 ,  C07D401/06 ,  C07D401/12 ,  C07D471/04

Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Abstract translation: 本发明包括可用于抑制细胞中ezrin蛋白或抑制癌细胞生长的下式（I）化合物或其药学上可接受的盐或前药的化合物和药物组合物。

公开(公告)号：US09758481B2

公开(公告)日：2017-09-12

申请号：US14696005

申请日：2015-04-24

Applicant: Georgetown University

Inventor： Jeffrey A. Toretsky ,  Aykut Uren ,  Milton Lang Brown ,  Yali Kong

IPC: C07D209/38 ,  A61K31/404 ,  C07D401/06 ,  A61K38/00 ,  C07K7/08 ,  C07K7/06 ,  A61K45/06

CPC classification number: C07D209/38 ,  A61K31/404 ,  A61K38/00 ,  A61K45/06 ,  C07D401/06 ,  C07K7/06 ,  C07K7/08

Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

公开(公告)号：US09511050B2

公开(公告)日：2016-12-06

申请号：US15030713

申请日：2014-10-20

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/405 ,  A61K31/404 ,  A61K45/06 ,  A61K47/40

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Abstract translation: 本文提供的方法和组合物涉及癌症的治疗。 在一些实施方案中，所述组合物可用于治疗癌症，包括多形性成胶质细胞瘤和肺癌。

公开(公告)号：US20140135325A1

公开(公告)日：2014-05-15

申请号：US14047362

申请日：2013-10-07

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Mikell Paige ,  Jeffrey A. Torestsky ,  Aykut Uren ,  George Kosturko ,  Gullay Bulut

IPC: C07D413/12 ,  C07D237/30 ,  C07D401/12 ,  C07D217/24 ,  C07D215/38 ,  C07D401/06 ,  C07D471/04

CPC classification number: C07D413/12 ,  C07D209/48 ,  C07D215/24 ,  C07D215/38 ,  C07D217/24 ,  C07D237/30 ,  C07D401/06 ,  C07D401/12 ,  C07D471/04

Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Abstract translation: 本发明包括可用于抑制细胞中ezrin蛋白或抑制癌细胞生长的下式（I）化合物或其药学上可接受的盐或前药的化合物和药物组合物。

公开(公告)号：US20180148437A1

公开(公告)日：2018-05-31

申请号：US15383413

申请日：2016-12-19

Applicant: Georgetown University

Inventor： Milton L. Brown ,  Mikell Paige ,  Jeffrey A. Torestsky ,  Aykut Uren ,  George Kosturko ,  Gullay Bulut

IPC: C07D413/12 ,  C07D401/12 ,  C07D215/24 ,  C07D471/04 ,  C07D209/48 ,  C07D215/38 ,  C07D401/06 ,  C07D237/30 ,  C07D217/24

CPC classification number: C07D413/12 ,  C07D209/48 ,  C07D215/24 ,  C07D215/38 ,  C07D217/24 ,  C07D237/30 ,  C07D401/06 ,  C07D401/12 ,  C07D471/04

Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growh of a cancer cell.

公开(公告)号：US09714222B2

公开(公告)日：2017-07-25

申请号：US15040840

申请日：2016-02-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38 ,  C07D209/34

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US20160263086A1

公开(公告)日：2016-09-15

申请号：US15030713

申请日：2014-10-20

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/404 ,  A61K47/40 ,  A61K45/06

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Abstract translation: 本文提供的方法和组合物涉及癌症的治疗。 在一些实施方案中，所述组合物可用于治疗癌症，包括多形性成胶质细胞瘤和肺癌。

公开(公告)号：US20160159741A1

公开(公告)日：2016-06-09

申请号：US15040840

申请日：2016-02-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US09290449B2

公开(公告)日：2016-03-22

申请号：US14388671

申请日：2013-04-11

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38 ,  C07D209/34

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

Abstract translation: 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。