公开(公告)号：US20170157089A1

公开(公告)日：2017-06-08

申请号：US15365794

申请日：2016-11-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/404 ,  A61K47/40 ,  A61K45/06

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

公开(公告)号：US09714222B2

公开(公告)日：2017-07-25

申请号：US15040840

申请日：2016-02-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38 ,  C07D209/34

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US20160263086A1

公开(公告)日：2016-09-15

申请号：US15030713

申请日：2014-10-20

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/404 ,  A61K47/40 ,  A61K45/06

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Abstract translation: 本文提供的方法和组合物涉及癌症的治疗。 在一些实施方案中，所述组合物可用于治疗癌症，包括多形性成胶质细胞瘤和肺癌。

公开(公告)号：US20190262370A1

公开(公告)日：2019-08-29

申请号：US16340831

申请日：2017-10-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： Aykut Üren ,  Haydar Celik ,  Jeffrey A. Toretsky

IPC: A61K31/7076 ,  A61K31/506 ,  A61P35/00 ,  A61K9/00 ,  A61P37/06

Abstract: Provided herein are methods of treating cancer in a subject. Also provided are methods of treating autoimmune disorders. The methods comprise administering to the subject an effective amount of a CD99 inhibitor.

公开(公告)号：US09758481B2

公开(公告)日：2017-09-12

申请号：US14696005

申请日：2015-04-24

Applicant: Georgetown University

Inventor： Jeffrey A. Toretsky ,  Aykut Uren ,  Milton Lang Brown ,  Yali Kong

IPC: C07D209/38 ,  A61K31/404 ,  C07D401/06 ,  A61K38/00 ,  C07K7/08 ,  C07K7/06 ,  A61K45/06

CPC classification number: C07D209/38 ,  A61K31/404 ,  A61K38/00 ,  A61K45/06 ,  C07D401/06 ,  C07K7/06 ,  C07K7/08

Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

公开(公告)号：US09511050B2

公开(公告)日：2016-12-06

申请号：US15030713

申请日：2014-10-20

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Aykut Uren

IPC: A61K31/405 ,  A61K31/404 ,  A61K45/06 ,  A61K47/40

CPC classification number: A61K31/404 ,  A61K45/06 ,  A61K47/40 ,  C07D209/38

Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Abstract translation: 本文提供的方法和组合物涉及癌症的治疗。 在一些实施方案中，所述组合物可用于治疗癌症，包括多形性成胶质细胞瘤和肺癌。

公开(公告)号：US11202792B2

公开(公告)日：2021-12-21

申请号：US16340831

申请日：2017-10-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： Aykut Üren ,  Haydar Celik ,  Jeffrey A. Toretsky

IPC: A61K31/7076 ,  A61P37/06 ,  A61P35/00 ,  A61K9/00 ,  A61K31/506 ,  A61K45/06

Abstract: Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.

公开(公告)号：US20160159741A1

公开(公告)日：2016-06-09

申请号：US15040840

申请日：2016-02-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

公开(公告)号：US09290449B2

公开(公告)日：2016-03-22

申请号：US14388671

申请日：2013-04-11

Applicant: GEORGETOWN UNIVERSITY

Inventor： Jeffrey A. Toretsky ,  Milton Lang Brown ,  Perrer N. Tosso ,  Aykut Uren ,  Yali Kong

IPC: C07D209/38 ,  C07D209/34

CPC classification number: C07D209/38 ,  C07D209/34

Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

Abstract translation: 提供了与EWS-FLI1蛋白抑制剂有关的化合物，组合物和方法。 该化合物可用于治疗包括尤文氏肉瘤肿瘤家族在内的癌症。

公开(公告)号：US20150329488A1

公开(公告)日：2015-11-19

申请号：US14696005

申请日：2015-04-24

Applicant: Georgetown University

Inventor： Jeffrey A. Toretsky ,  Aykut Uren ,  Milton Lang Brown ,  Yali Kong

IPC: C07D209/38 ,  A61K45/06 ,  A61K31/404

CPC classification number: C07D209/38 ,  A61K31/404 ,  A61K38/00 ,  A61K45/06 ,  C07D401/06 ,  C07K7/06 ,  C07K7/08

Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

Abstract translation: 提供了作为EWS-FLI1蛋白抑制剂的肽和化合物。 肽和化合物可用于治疗尤文氏肉瘤的肿瘤家族。 还提供了制备化合物的方法和鉴定EWS-FLI1蛋白抑制剂的测定法。