- 专利标题: Trifunctional crosslinking reagents
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申请号: US13982596申请日: 2012-01-30
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公开(公告)号: US09766235B2公开(公告)日: 2017-09-19
- 发明人: Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
- 申请人: Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
- 申请人地址: CH Zurich
- 专利权人: ETH Zurich
- 当前专利权人: ETH Zurich
- 当前专利权人地址: CH Zurich
- 代理机构: Renner, Otto, Boisselle & Sklar, LLP
- 优先权: EP11000731 20110131
- 国际申请: PCT/EP2012/000392 WO 20120130
- 国际公布: WO2012/104051 WO 20120809
- 主分类号: G01N33/566
- IPC分类号: G01N33/566 ; C07D495/04 ; G01N33/58
摘要:
The present invention relates to trifunctional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) an optionally protected aromatic hydrazine group for the capturing of oxidized receptor-glycopeptides and (iii) an affinity group for the detection, isolation and purification of captured glycopeptides, their methods of production, as well as their use in methods for detecting, identifying and characterizing interactions between ligands and their corresponding glycoprotein target receptors on living cells and in biological fluids.
公开/授权文献
- US20140011212A1 TRIFUNCTIONAL CROSSLINKING REAGENTS 公开/授权日:2014-01-09