- 专利标题： Indazole compounds useful as ketohexokinase inhibitors
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申请号： US14338816申请日： 2014-07-23
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公开(公告)号： US09771375B2公开(公告)日： 2017-09-26
- 发明人: Xuqing Zhang , Marta C Abad , Alan C. Gibbs , Gee-Hong Kuo , Fengbin Song , Zhihua Sui , Lawrence C. Kuo
- 申请人： JANSSEN PHARMACEUTICA NV
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 代理机构： Baker & Hostetler LLP
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P3/10 ; A61P3/04 ; A61P3/06 ; C07D471/04 ; C07D491/08 ; C07D231/56 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/10 ; C07D403/12 ; C07D487/10 ; A61K31/437
摘要：
The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
公开/授权文献
- US20140336170A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS 公开/授权日：2014-11-13
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