-
公开(公告)号：US20190367469A1
公开(公告)日：2019-12-05
申请号：US16348304
申请日：2017-11-08
发明人： Micheal Gaul , Gee-Hong Kuo , Guozhang Xu , Yin Liang
IPC分类号： C07D309/10
摘要： The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.
-
2.发明授权公开(公告)号：US10131648B2
公开(公告)日：2018-11-20
申请号：US15697867
申请日：2017-09-07
发明人： Hui Huang , Gee-Hong Kuo , Mark R. Player , Shyh-Ming Yang , Yue-Mei Zhang
IPC分类号： C07D409/10 , C07D333/54 , C07D333/56 , C07D409/04 , C07D409/12 , C07D409/14 , C07D495/10 , A61K31/381 , A61K31/4436 , C07D233/56 , C07D409/02
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R5, R6, W, and A are defined herein.
-
公开(公告)号：US09771375B2
公开(公告)日：2017-09-26
申请号：US14338816
申请日：2014-07-23
发明人： Xuqing Zhang , Marta C Abad , Alan C. Gibbs , Gee-Hong Kuo , Fengbin Song , Zhihua Sui , Lawrence C. Kuo
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P3/04 , A61P3/06 , C07D471/04 , C07D491/08 , C07D231/56 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D487/10 , A61K31/437
CPC分类号： C07D491/08 , C07D231/56 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
-
4.发明授权Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors 有权用作SCD 1抑制剂的取代的哌啶基 - 哒嗪衍生物公开(公告)号：US09102669B2
公开(公告)日：2015-08-11
申请号：US14363051
申请日：2012-12-05
发明人： Shyh-Ming Yang , Gee-Hong Kuo , Micheal D. Gaul , Thomas A. Rano
IPC分类号： C07D295/00 , C07D417/14 , C07D401/14 , C07D413/14 , C07D409/14
CPC分类号： C07D417/14 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
摘要翻译： 本发明涉及新颖的哌啶基 - 哒嗪衍生物，含有它们的药物组合物及其作为SCD1抑制剂的用途，可用于治疗肥胖症，II型糖尿病和其它相关的代谢紊乱。
-
公开(公告)号：US20220009906A1
公开(公告)日：2022-01-13
申请号：US17356575
申请日：2021-06-24
发明人： Guozhang Xu , Eugene B. Grant , Gee-Hong Kuo , Micheal D. Gaul
IPC分类号： C07D403/04 , C07D409/14 , C07D403/14 , C07D405/14 , C07D401/14 , C07D471/10 , C07D491/107 , C07D498/10
摘要： The present invention is directed to isoindolin-1-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GRK2, including, but not limited to, cardiac failure, cardiac hypertrophy, hypertension, Type II diabetes Mellitus, NASH, NAFLD, end stage chronic kidney disease, kidney failure, etc.
-
6.发明授权公开(公告)号：US11014917B2
公开(公告)日：2021-05-25
申请号：US16890331
申请日：2020-06-02
发明人： Guozhang Xu , Gee-Hong Kuo , Micheal Gaul
IPC分类号： C07D409/10 , C07D513/04 , C07D405/14 , C07D411/14 , C07D407/14
摘要： The present invention is directed to 5-fluoro-C-(aryl or heterocyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.
-
7.发明授权公开(公告)号：US10696662B2
公开(公告)日：2020-06-30
申请号：US16106104
申请日：2018-08-21
发明人： Guozhang Xu , Gee-Hong Kuo , Micheal Gaul
IPC分类号： C07D409/10 , C07D513/04 , C07D405/14 , C07D411/14 , C07D407/14
摘要： The present invention is directed to 5-fluoro-C-(aryl or hetercyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.
-
公开(公告)号：US20190192475A1
公开(公告)日：2019-06-27
申请号：US16292406
申请日：2019-03-05
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号： A61K31/277 , C07C323/20 , C07D333/28 , C07D333/16 , C07C323/62 , A61K31/192 , C07C317/22 , C07C59/70 , C07C59/68 , C07C323/60
CPC分类号： A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
-
9.发明授权公开(公告)号：US09790198B2
公开(公告)日：2017-10-17
申请号：US14877972
申请日：2015-10-08
发明人： Hui Huang , Gee-Hong Kuo , Mark R. Player , Shyh-Ming Yang , Yue-Mei Zhang
IPC分类号： C07D333/56 , C07D333/54 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D495/10 , A61K31/381 , A61K31/4436 , C07D233/56 , C07D409/02
CPC分类号： C07D333/54 , A61K31/381 , A61K31/4436 , C07D233/56 , C07D333/56 , C07D409/02 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D495/10
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R5, R6, W, and A are defined herein.
-
公开(公告)号：US09724322B2
公开(公告)日：2017-08-08
申请号：US15074125
申请日：2016-03-18
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号： A61K31/277 , A61K31/192 , C07C323/20 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
CPC分类号： A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.024 秒)
