公开(公告)号：US09771375B2

公开(公告)日：2017-09-26

申请号：US14338816

申请日：2014-07-23

申请人： JANSSEN PHARMACEUTICA NV

发明人： Xuqing Zhang ,  Marta C Abad ,  Alan C. Gibbs ,  Gee-Hong Kuo ,  Fengbin Song ,  Zhihua Sui ,  Lawrence C. Kuo

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06 ,  C07D471/04 ,  C07D491/08 ,  C07D231/56 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D487/10 ,  A61K31/437

CPC分类号： C07D491/08 ,  C07D231/56 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10

摘要： The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.