Invention Grant
- Patent Title: Method of treating cancer by administering EGFR and EGFR/IGFIR binding molecules
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Application No.: US14664290Application Date: 2015-03-20
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Publication No.: US09771411B2Publication Date: 2017-09-26
- Inventor: Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Christopher L. Frank
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/39 ; C07K14/435 ; C07K14/475 ; C07K14/78 ; C07K16/28 ; A61K39/395 ; A61K45/06 ; C07K14/705 ; A61K39/00
Abstract:
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
Public/Granted literature
- US20150259398A1 BISPECIFIC EGFR/IGFIR BINDING MOLECULES Public/Granted day:2015-09-17
Information query
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