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公开(公告)号：US10954286B2
公开(公告)日：2021-03-23
申请号：US16206551
申请日：2018-11-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/16 , A61K38/39 , C07K14/78 , C07K16/28 , C07K14/475 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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公开(公告)号：US09234028B2
公开(公告)日：2016-01-12
申请号：US13956952
申请日：2013-08-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
IPC: A61K38/17 , A61K38/39 , C07K14/78 , C07K14/435 , C07K16/28 , C07K14/765 , C07K14/79 , C07K19/00
CPC classification number: C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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Patent Agency Ranking
公开(公告)号：US09920108B2
公开(公告)日：2018-03-20
申请号：US14954596
申请日：2015-11-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
CPC classification number: C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US10781247B2
公开(公告)日：2020-09-22
申请号：US15886118
申请日：2018-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US09017655B2
公开(公告)日：2015-04-28
申请号：US13692555
申请日：2012-12-03
Applicant: Bristol-Myers Squibb Company
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/17 , A61K38/39 , C07K14/78 , C07K14/435 , C07K14/475 , C07K16/28
CPC classification number: C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
Abstract translation: 本发明涉及包含EGFR结合结构域和用于诊断，研究和治疗应用的不同IGFIR结合结构域的双特异性分子。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码创新蛋白质的多核苷酸的载体。 示例性双特异性分子包括基于第十纤连蛋白III型结构域的抗体样蛋白二聚体。
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公开(公告)号：US10183987B2
公开(公告)日：2019-01-22
申请号：US15684595
申请日：2017-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/16 , A61K38/39 , C07K14/475 , C07K14/78 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/63 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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公开(公告)号：US09771411B2
公开(公告)日：2017-09-26
申请号：US14664290
申请日：2015-03-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/16 , A61K38/39 , C07K14/435 , C07K14/475 , C07K14/78 , C07K16/28 , A61K39/395 , A61K45/06 , C07K14/705 , A61K39/00
CPC classification number: C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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