Systems and methods for multi-protocol serial communication interfaces are described. One example system includes an interface module including a buffer for storing a protocol selection. The system includes a protocol module coupled to the interface module and configured for providing one or more serial communication protocols. Based on the protocol selection, one of the serial communication protocols is selected. The system also includes a serial engine module coupled to the interface module and the protocol module. The serial engine module is configured for transmitting and receiving data or commands based on the selected serial communication protocol.