- 专利标题: Methods of generating oligodendrocytes and cell populations comprising same
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申请号: US13817535申请日: 2011-08-14
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公开(公告)号: US09783781B2公开(公告)日: 2017-10-10
- 发明人: Shimon Slavin , Chaya Brodie
- 申请人: Shimon Slavin , Chaya Brodie
- 申请人地址: IL Tel-Aviv
- 专利权人: EXOSTEM BIOTEC LTD.
- 当前专利权人: EXOSTEM BIOTEC LTD.
- 当前专利权人地址: IL Tel-Aviv
- 代理机构: The Roy Gross Law Firm, LLC
- 代理商 Roy Gross
- 国际申请: PCT/IL2011/000660 WO 20110814
- 国际公布: WO2012/023132 WO 20120223
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; A61K35/12 ; C12N5/079
摘要:
A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.