The disclosure provides for interference mitigation for wireless signals in unlicensed spectrum. A wireless device may receive a combined signal including a first radio access technology (RAT) signal and a second RAT signal. The wireless device may generate, using a first RAT receiver in a first processing path, a channel estimate for the first RAT signal based on a previously decoded signal of the first RAT. The wireless device may reduce interference to the second RAT signal caused by the first RAT signal, in a second processing path, using the channel estimate. The wireless device may further decode the second RAT signal. The wireless device may remodulate the decoded signal using a transmitter to generate a remodulated second RAT signal. The remodulated second RAT signal may be canceled from the combined signal. The wireless device may decode a remaining portion of the combined signal including the first RAT signal.