- 专利标题: Modulation of bacterial quorum sensing with synthetic ligands
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申请号: US14328515申请日: 2014-07-10
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公开(公告)号: US09796694B2公开(公告)日: 2017-10-24
- 发明人: Helen E. Blackwell , Grant D. Geske , Jennifer C. Campbell Butler
- 申请人: WISCONSIN ALUMNI RESEARCH FOUNDATION
- 申请人地址: US WI Madison
- 专利权人: Wisconsin Alumni Research Foundation
- 当前专利权人: Wisconsin Alumni Research Foundation
- 当前专利权人地址: US WI Madison
- 代理机构: Lathrop Gage LLP
- 主分类号: C07D307/33
- IPC分类号: C07D307/33 ; A61K31/365 ; C07D307/32 ; C07D309/30 ; C07D333/32 ; C07D405/12 ; C07D407/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C12N1/36
摘要:
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.