Methods and apparatus to increase cloud availability and silicon isolation using secure enclaves. A compute platform is configured to host a compute domain in which a plurality of secure enclaves are implemented. In conjunction with creating and deploying secure enclaves, mapping information is generated that maps the secure enclaves to platform/CPU resources, such as Intellectual Property blocks (IP) belong to the secure enclaves. In response to platform error events caused by errant platform/CPU resources, the secure enclave(s) belonging to the errant platform/CPU are identified via the mapping information, and an interrupt is directed to that/those secure enclave(s). In response to the interrupt, a secure enclave may be configured to one or more of handle the error, pass information to another secure enclave, and teardown the enclave. The secure enclave may execute an interrupt service routine that causes the errant platform/CPU resource to reset without resetting the entire platform or CPU, as applicable.