- 专利标题： Generation of neural stem cells and motor neurons
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申请号： US14380165申请日： 2013-02-21
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公开(公告)号： US09803175B2公开(公告)日： 2017-10-31
- 发明人: Chaya Brodie , Shimon Slavin
- 申请人： BrainStem Biotec Ltd. , Henry Ford Health System
- 申请人地址： IL Tel Aviv US MI Detroit
- 专利权人： EXOSTEM BIOTEC LTD.,HENRY FORD HEALTH SYSTEM
- 当前专利权人： EXOSTEM BIOTEC LTD.,HENRY FORD HEALTH SYSTEM
- 当前专利权人地址： IL Tel Aviv US MI Detroit
- 代理机构： The Roy Gross Law Firm, LLC
- 代理商 Roy Gross
- 国际申请： PCT/IB2013/051429 WO 20130221
- 国际公布： WO2013/124816 WO 20130829
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K35/12 ; C12N5/0797 ; C12N5/0793 ; A61K35/28 ; C12Q1/68
摘要：
A method of generating neural stem cells or motor neurons is disclosed, the method comprising up-regulating a level of at least one exogenous miRNA and/or down-regulating at least one miRNA using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs) or down-regulating Related to testis-specific, vespid and pathogenesis protein 1 (RTVP-1).
公开/授权文献
- US20150037299A1 GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS 公开/授权日：2015-02-05
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