The present invention relates to a multi-input and multi-output communication method in a large-scale antenna system. An MIMO transmission method according to the present invention includes: obtaining statistical channel information on at least one terminal, dividing terminals into a plurality of classes and a plurality of groups based on the statistical channel information, wherein the groups depend on the classes; determining a group beam-forming matrix for each of the divided groups; performing a group beamforming transmission by group based on the group beam-forming matrix to obtain instantaneous channel information; and scheduling terminals based on the instantaneous channel information. Thus, it is possible to decrease the complexity in a scheduling and precoding calculation without an increase in the amount of wireless resources that are required for providing feedback for a reference signal and channel status information.