- 专利标题： Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor
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申请号： US14758427申请日： 2013-02-06
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公开(公告)号： US09821062B2公开(公告)日： 2017-11-21
- 发明人: Ravindra K. Pandey , Nayan Patel , Manivannan Ethirajan , Hua Bai , Zhenliang Chen
- 申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- 申请人地址： CN Zhejiang
- 专利权人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- 当前专利权人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： CN Zhejiang
- 代理机构： Ladas & Parry LLP
- 优先权： CN201210598014 20121228
- 国际申请： PCT/CN2013/071445 WO 20130206
- 国际公布： WO2014/101339 WO 20140703
- 主分类号： C07B47/00
- IPC分类号： C07B47/00 ; C07D487/22 ; A61K41/00 ; C09B23/04 ; C07D403/14 ; C07D209/60
摘要：
Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2′″ position, so that tumor highly absorbs the conjugates.