- 专利标题： Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
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申请号： US15105713申请日： 2014-12-18
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公开(公告)号： US09822107B2公开(公告)日： 2017-11-21
- 发明人: Brian M. Andresen , Kenneth L. Arrington , Ryan D. Otte , John Michael Ellis , John W. Butcher , Alan B. Northrup , Joel S. Robichaud , Jacques Yves Gauthier , Jean-Francois Fournier
- 申请人： Brian M. Andresen , Kenneth L. Arrington , Ryan D. Otte , John Michael Ellis , John W. Butcher , Alan B. Northrup , Joel S. Robichaud , Jacques Yves Gauthier , Jean-Francois Fournier , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway CA Kirkland, Quebec
- 专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人地址： US NJ Rahway CA Kirkland, Quebec
- 代理商 Eric A. Meade; Catherine D. Fitch
- 国际申请： PCT/US2014/071026 WO 20141218
- 国际公布： WO2015/095445 WO 20150625
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D417/14 ; A61K31/506 ; A61K31/5377 ; A61K31/538
摘要：
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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