Abstract:
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
Abstract:
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
Abstract:
A large round baler is equipped with an enveloping arrangement that moves a run of enveloping material to the circumferential surface of a bale with a pivot arm including a driver having projections in the form of teeth that can be caused to penetrate the enveloping material to cause a positive locking with the run of enveloping material so that the enveloping material may be selectively inserted into the baling chamber at the beginning of a wrapping cycle and engaged with a contact plate to effect separation of the enveloping material once a predetermined number of wraps have been applied to the circumference of the bale.
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract:
Substituted 2-naphthoic acids of structural formula are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract:
A large round baler has an expansible baling chamber defined, in part, by a plurality of side-by-side mounted belts that act to roll up crop to form a bale within the chamber. The baler is equipped with a twine wrapping arrangement which leaves loose twine ends adjacent one of the ends of the wrapped baler. In order to secure these loose ends, there is provided an adhesive tape dispensing arrangement, which cooperates with the bale-forming belt that is aligned with the area of the bale on which the loose twine ends lie, so that a length of adhesive tape is selectively fed into the bale chamber by the bale-forming belt such that it is wrapped about the bale in covering relationship to the loose twine ends. A separating arrangement is provided for causing that part of the length of adhesive tape that is wrapped about the bale to be separated from the supply roll of tape.