Invention Grant
- Patent Title: Populations of hematopoietic progenitors and methods of enriching stem cells therefor
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Application No.: US14359517Application Date: 2012-11-21
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Publication No.: US09834754B2Publication Date: 2017-12-05
- Inventor: Gordon Keller , Juan Carlos Zuniga-Pflucker , Marion J. Kennedy , Christopher Michael Sturgeon , Andrea Ditadi , Geneve Sheandra Awong
- Applicant: University Health Network , Sunnybrook Research Institute
- Applicant Address: CA Toronto CA Toronto
- Assignee: UNIVERSITY HEALTH NETWORK,SUNNYBROOK RESEARCH INSTITUTE
- Current Assignee: UNIVERSITY HEALTH NETWORK,SUNNYBROOK RESEARCH INSTITUTE
- Current Assignee Address: CA Toronto CA Toronto
- Agency: J.A. Lindeman & Co. PLLC
- International Application: PCT/CA2012/001076 WO 20121121
- International Announcement: WO2013/075222 WO 20130530
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/0789 ; G01N33/569

Abstract:
There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34+CD43−, CD31+CD43− and CD144+CD43−. Also provided are populations of hematopoietic progenitors obtained by the methods described herein.
Public/Granted literature
- US20140322808A1 POPULATIONS OF HEMATOPOIETIC PROGENITORS AND METHODS OF ENRICHING STEM CELLS THEREFOR Public/Granted day:2014-10-30
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