- 专利标题: Inhibitors of NEDD8-activating enzyme
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申请号: US14326051申请日: 2014-07-08
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公开(公告)号: US09850214B2公开(公告)日: 2017-12-26
- 发明人: Ashley Sue McCarron , Todd B. Sells , Matthew Stirling , Stephen G. Stroud
- 申请人: Millennium Pharmaceuticals, Inc.
- 申请人地址: US MA Cambridge
- 专利权人: MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人: MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Sterne, Kessler, Goldstein and Fox P.L.L.C.
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; C07D239/02 ; C07D239/47 ; C07D239/46 ; C07D473/02
摘要:
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
公开/授权文献
- US20150011572A1 INHIBITORS OF NEDD8-ACTIVATING ENZYME 公开/授权日:2015-01-08
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