公开(公告)号：US11492587B2

公开(公告)日：2022-11-08

申请号：US16481962

申请日：2018-01-31

申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION ,  MS BIOTECH, INC.

发明人： James Scott Drouillard ,  Celine Caroline Aperce ,  Gina Rae Herren ,  Tara Jo Ellerman ,  Ciana Marie Scaletti ,  Katherine Van Jordan ,  James Morris Lattimer ,  Scott Beyer ,  Solange Uwituze ,  Teresa Lea Douthit ,  Christina Denise Gunkel

IPC分类号： C12N1/20 ,  C12N1/04 ,  A23K50/10 ,  A23K50/20 ,  A23K50/75 ,  A23K10/18 ,  A61P31/04 ,  A61K35/744

摘要： The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.

公开(公告)号：US11243753B2

公开(公告)日：2022-02-08

申请号：US16177813

申请日：2018-11-01

申请人： salesforce.com, inc.

发明人： Steven Holly ,  Eugene Oksman ,  Amit Lubovsky ,  Jenton Lee

IPC分类号： G06F8/60 ,  G06F8/65

摘要： Embodiments of apparatus, systems, and methods are described for creating and configuring a custom mobile application (app), with communities, using a graphical user interface (GUI). The GUI enables selection of a pre-configured template for creating a custom mobile app for a user group of a customer relationship management system or of an existing community. The GUI enables entry of metadata comprising identification of a specific user community of the custom mobile app. The GUI enables selection of a distribution model for the custom mobile app for the specific user community, further allowing entry of additional metadata comprising distribution model parameters and packaging parameters of the app. The GUI enables packaging of the app using the packaging parameters and publishing of the app to an app store using the distribution model parameters. The app becomes accessible from the app store for installation on a mobile device according to the distribution model.

公开(公告)号：US10545135B2

公开(公告)日：2020-01-28

申请号：US12224839

申请日：2007-03-06

申请人： Geeta Shroff

发明人： Geeta Shroff

IPC分类号： G01N33/50 ,  A61K35/48 ,  A61K35/545 ,  C12N5/073 ,  C12N5/0735 ,  A61K35/12

摘要： The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hES) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media. This invention further relates to the isolation, culture, maintenance, expansion, differentiation, storage, and preservation of such stem cells.

公开(公告)号：US10377732B2

公开(公告)日：2019-08-13

申请号：US15570781

申请日：2016-11-29

申请人： F.I.S.—Fabbrica Italiana Sintetici S.p.A.

发明人： Paolo Maragni ,  Massimo Verzini

IPC分类号： C07D309/14 ,  C07D317/28 ,  C07D317/72 ,  C07D303/36 ,  C07C271/16 ,  C07C309/73 ,  C07C233/18

摘要： The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).

公开(公告)号：US10287586B2

公开(公告)日：2019-05-14

申请号：US15661750

申请日：2017-07-27

申请人： The University of Western Australia

发明人： Stephen Donald Wilson ,  Sue Fletcher ,  Abbie Adams ,  Penny Meloni

IPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/11

摘要： An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.

公开(公告)号：US10272146B2

公开(公告)日：2019-04-30

申请号：US15458792

申请日：2017-03-14

申请人： Sanaria Inc.

发明人： B. Kim Lee Sim ,  Minglin Li ,  Richard E. Stafford ,  Stephen L. Hoffman

IPC分类号： A61K39/002 ,  A61K39/015 ,  A61K9/00 ,  A61K31/4706 ,  A61K39/00

摘要： Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.

公开(公告)号：US10189587B2

公开(公告)日：2019-01-29

申请号：US14112853

申请日：2012-04-18

申请人： Gaétan Demers

发明人： Gaétan Demers

IPC分类号： B65B9/06 ,  B32B37/20 ,  H01B7/08 ,  B32B5/02 ,  B32B7/12 ,  B32B27/12 ,  B32B3/08 ,  B32B38/18 ,  D03D1/00 ,  H05K1/03 ,  B32B37/12 ,  B65B15/04 ,  B32B37/00

摘要： A process for a continuous production of an encapsulated component web by conveying at least two continuous encapsulation films along a longitudinal axis of a production line with at least one of the two continuous encapsulation films having an adhesive layer on an inner face thereof; inserting at least one encapsulatable component between the two continuous encapsulation films; conveying an assembly including the two continuous encapsulation films with the at least one encapsulatable component extending therebetween in a nip defined in between at least two contiguous rolls; and laminating the assembly to encapsulate the at least one encapsulatable component between the two continuous encapsulation films. There is also provided an apparatus for carrying out the process.

公开(公告)号：US09850311B2

公开(公告)日：2017-12-26

申请号：US11589993

申请日：2006-10-31

申请人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

发明人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

IPC分类号： C07K16/00 ,  C07K16/30 ,  A61K45/06 ,  C07K16/28 ,  C07K16/46 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/468 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： An isolated antibody that specifically binds to an extracellular domain of two or more human FZD receptors and inhibits growth of tumor cells is described. Also described is a method of treating cancer comprising administering an antibody of the present disclosure in an amount effective to inhibit tumor cell growth.

公开(公告)号：US09850214B2

公开(公告)日：2017-12-26

申请号：US14326051

申请日：2014-07-08

申请人： Millennium Pharmaceuticals, Inc.

发明人： Ashley Sue McCarron ,  Todd B. Sells ,  Matthew Stirling ,  Stephen G. Stroud

IPC分类号： A61K31/505 ,  C07D239/02 ,  C07D239/47 ,  C07D239/46 ,  C07D473/02

CPC分类号： C07D239/47 ,  C07D239/46 ,  C07D473/02

摘要： Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.

公开(公告)号：US09724430B2

公开(公告)日：2017-08-08

申请号：US14864265

申请日：2015-09-24

申请人： Intrexon Corporation

发明人： Bethany Lynn Merenick ,  Robert P. Beech ,  Thomas D. Reed ,  Anna P. Tretiakova ,  Richard E. Peterson

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/63 ,  A61K48/00 ,  A61K31/7088 ,  C12N15/85 ,  A01K67/00 ,  A61K35/12

CPC分类号： A61K48/0066 ,  A61K31/7088 ,  A61K35/12 ,  C12N15/635 ,  C12N15/85 ,  C12N2510/02 ,  C12N2830/002 ,  C12N2830/15

摘要： The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.