Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassium channel
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Application No.: US15505277Application Date: 2015-10-26
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Publication No.: US09850245B2Publication Date: 2017-12-26
- Inventor: Alexander Pasternak , Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Haifeng Tang , Xin Gu , Reynalda K. DeJesus , Jessica Frie , Qinghong Fu , Takao Suzuki , Zhifa Pu
- Applicant: Merck Sharp & Dohme Corp. , Alexander Pasternak , Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Haifeng Tang , Xin Gu , Reynalda K. DeJesus , Jessica Frie , Qinghong Fu , Takao Suzuki , Zhifa Pu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- Priority: WOPCT/CN2014/089998 20141031
- International Application: PCT/US2015/057279 WO 20151026
- International Announcement: WO2016/069426 WO 20160506
- Main IPC: C07D471/10
- IPC: C07D471/10 ; A61K31/499 ; C07D498/10 ; A61K31/5386 ; A61K31/55 ; A61K31/435 ; A61K31/537 ; C07D498/20 ; A61K31/553 ; A61K45/06
Abstract:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Public/Granted literature
- US20170275283A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Public/Granted day:2017-09-28
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