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公开(公告)号：US09850245B2
公开(公告)日：2017-12-26
申请号：US15505277
申请日：2015-10-26
Applicant: Merck Sharp & Dohme Corp. , Alexander Pasternak , Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Haifeng Tang , Xin Gu , Reynalda K. DeJesus , Jessica Frie , Qinghong Fu , Takao Suzuki , Zhifa Pu
Inventor： Alexander Pasternak , Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Haifeng Tang , Xin Gu , Reynalda K. DeJesus , Jessica Frie , Qinghong Fu , Takao Suzuki , Zhifa Pu
IPC: C07D471/10 , A61K31/499 , C07D498/10 , A61K31/5386 , A61K31/55 , A61K31/435 , A61K31/537 , C07D498/20 , A61K31/553 , A61K45/06
CPC classification number: C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/499 , A61K31/537 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K45/06 , C07D487/10 , C07D498/10 , C07D498/20 , A61K2300/00
Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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2.发明申请4-AMINO-1H-PYRIMIDIN-2-ONE BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 有权4-氨基-1H-吡嗪二酮化合物，包含它们的组合物及其使用方法公开(公告)号：US20080182847A1
公开(公告)日：2008-07-31
申请号：US11954421
申请日：2007-12-12
Applicant: David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
Inventor： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
IPC: A61K31/517 , A61K31/513 , C07D403/02
CPC classification number: C07D239/47 , C07D239/54 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04
Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:
Abstract translation: 公开了4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。 特定的化合物具有式I：
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3.发明申请O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER 有权O型连接的吡啶基-4-胺基化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US20080146571A1
公开(公告)日：2008-06-19
申请号：US11954433
申请日：2007-12-12
Applicant: David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
Inventor： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC: A61K31/506 , C07D239/47 , C07D403/12 , A61K31/519 , A61P35/00 , A61K31/5377 , C07D491/044 , C07D413/12
CPC classification number: C07D401/12 , C07D401/14 , C07D409/14
Abstract: O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
Abstract translation: 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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公开(公告)号：US20170275283A1
公开(公告)日：2017-09-28
申请号：US15505277
申请日：2015-10-26
Applicant: Alexander PASTERNAK , Fa-Xiang DING , Shuzhi DONG , Jinlong JIANG , Haifeng TANG , Xin GU , Reynalda K. DEJESUS , Jessica FRIE , Qinghong FU , Takao SUZUKI , Zhifa PU , Merck Sharp & Dohme Corp.
Inventor： Alexander Pasternak , Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Haifeng Tang , Xin Gu , Reynalda K. DeJesus , Jessica Frie , Qinghong Fu , Takao Suzuki , Zhifa Pu
IPC: C07D471/10 , C07D498/10 , A61K31/5386 , A61K45/06 , A61K31/435 , A61K31/537 , C07D498/20 , A61K31/553 , A61K31/499 , A61K31/55
CPC classification number: C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/499 , A61K31/537 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K45/06 , C07D487/10 , C07D498/10 , C07D498/20 , A61K2300/00
Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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5.发明授权4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use 有权4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其使用方法公开(公告)号：US08093245B2
公开(公告)日：2012-01-10
申请号：US11954421
申请日：2007-12-12
Applicant: David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
Inventor： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
IPC: C07D239/47 , C07D403/04 , A61K31/506
CPC classification number: C07D239/47 , C07D239/54 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04
Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:
Abstract translation: 公开了4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。 特定的化合物具有式I：
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Patent Agency Ranking
公开(公告)号：US07683122B2
公开(公告)日：2010-03-23
申请号：US11390939
申请日：2006-03-27
Applicant: Doetze Jakob Sikkema , David J. Rodini , Qinghong Fu Adkins , Steven R. Allen , Georg Valentin Martin , Ralf Demuth , Michael Schelhaas
Inventor： Doetze Jakob Sikkema , David J. Rodini , Qinghong Fu Adkins , Steven R. Allen , Georg Valentin Martin , Ralf Demuth , Michael Schelhaas
Abstract: Disclosed are processes for preparing polyareneazole polymers including contacting a molar excess of a free base in water with a terephthalic acid salt to form an aqueous mixture, adjusting the pH to precipitate a monomer complex, contacting the monomer complex with metal powder, and polymerizing the monomer complex. Polyareneazoles, filaments and yarns are also disclosed.
Abstract translation: 公开了制备聚芳腈聚合物的方法，包括使摩尔过量的游离碱与水中的游离碱与对苯二甲酸盐接触以形成水性混合物，调节pH以沉淀单体配合物，使单体配合物与金属粉末接触，并使单体聚合 复杂。 还公开了聚芳ne唑，长丝和纱线。
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公开(公告)号：US20160324833A1
公开(公告)日：2016-11-10
申请号：US15101481
申请日：2014-12-19
Applicant: Shuzhi DONG , Alexander PASTERNAK , Xin GU , Qinghong FU , Jinlong JIANG , Fa-Xiang DING , Haifeng TANG , Reynalda K. DEJESUS , Takao SUZUKI , MERCK SHARP & DOHME CORP.
Inventor： Shuzhi Dong , Alexander Pasternak , Xin Gu , Qinghong Fu , Jinlong Jiang , Fa-Xiang Ding , Haifeng Tang , Reynalda K. DeJesus , Takao Suzuki
IPC: A61K31/435 , C07D471/10 , A61K31/444 , A61K31/506 , A61K31/438 , C07D498/10 , A61K31/537 , A61K31/497 , C07D519/00 , A61K31/437 , A61K45/06 , A61K31/501
CPC classification number: A61K31/435 , A61K31/437 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/537 , A61K45/06 , C07D471/10 , C07D498/10 , C07D519/00 , A61K2300/00
Abstract: Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US07754846B2
公开(公告)日：2010-07-13
申请号：US11390859
申请日：2006-03-27
Applicant: Qinghong Fu Adkins , Doetze Jakob Sikkema , Steven R. Allen , David J. Rodini
Inventor： Qinghong Fu Adkins , Doetze Jakob Sikkema , Steven R. Allen , David J. Rodini
IPC: C08G63/78 , C08G63/81 , C08G63/02 , C08G63/46 , C08G63/183
CPC classification number: C08G61/02 , C08G61/10 , C08G61/12 , C08G61/122 , C08G73/06 , C08G73/0633 , C08G73/0694 , C08G73/18 , C08G73/22
Abstract: Disclosed are thermal processes for increasing polyareneazole inherent viscosities.
Abstract translation: 公开了用于增加聚are唑特性粘度的热处理。
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公开(公告)号：US09527830B2
公开(公告)日：2016-12-27
申请号：US14344681
申请日：2012-09-10
Applicant: Shawn Walsh , Alexander Pasternak , Brian Cato , Paul E. Finke , Jessica Frie , Qinghong Fu , Dooseop Kim , Barbara Pio , Aurash Shahripour , Zhi-Cai Shi , Haifeng Tang
Inventor： Shawn Walsh , Alexander Pasternak , Brian Cato , Paul E. Finke , Jessica Frie , Qinghong Fu , Dooseop Kim , Barbara Pio , Aurash Shahripour , Zhi-Cai Shi , Haifeng Tang
IPC: C07D403/14 , C07D401/10 , C07D405/14 , C07D413/14 , C07D403/10 , C07D405/06 , C07D405/12 , C07D487/04 , C07D211/28 , C07D211/62 , C07D211/48 , C07D471/08
CPC classification number: C07D401/10 , C07D211/28 , C07D211/48 , C07D211/62 , C07D403/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/08 , C07D487/04
Abstract: This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
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10.发明授权Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US08809579B2
公开(公告)日：2014-08-19
申请号：US13148577
申请日：2010-02-03
Applicant: Roman Kats-Kagan , Christian P. Stevenson , Xibin Liao , Qinghong Fu , Emma R. Parmee , Songnian Lin
Inventor： Roman Kats-Kagan , Christian P. Stevenson , Xibin Liao , Qinghong Fu , Emma R. Parmee , Songnian Lin
IPC: C07C229/00 , A01N43/04
CPC classification number: C07C235/42 , C07C235/46 , C07C255/54 , C07D213/64 , C07D215/233 , C07D277/64 , C07D333/16
Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
Abstract translation: 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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