Invention Grant
- Patent Title: Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
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Application No.: US14569583Application Date: 2014-12-12
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Publication No.: US09856496B2Publication Date: 2018-01-02
- Inventor: Xavier de Mollerat du Jeu
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Main IPC: C12N15/88
- IPC: C12N15/88 ; C07K14/00 ; A61K47/54 ; A61K47/64

Abstract:
The present invention is directed to non-naturally occurring peptides containing a membrane-penetrating amino acid sequence and further at least one polycationic moiety or peptide sequence. The peptides are suitable for use in delivery a cargo to the interior of a cell. Suitable cargo includes nucleic acid molecules (including DNA, RNA or PNA), polypeptides, or other biologically active molecules. The present invention is further directed to transfection complexes containing the non-naturally occurring peptides of the present invention in non-covalent association with at least one cationic lipid and a cargo to be delivered to the interior of a cell. The invention further relates to methods for the preparation and use of the non-naturally occurring peptides for the formation of transfection complexes and the delivery of a cargo to the interior of a cell in culture, an animal or a human. The invention also relates to compositions and kits useful for transfecting cells.
Public/Granted literature
- US20150211021A1 MEMBRANE-PENETRATING PEPTIDES TO ENHANCE TRANSFECTION AND COMPOSITIONS AND METHODS FOR USING SAME Public/Granted day:2015-07-30
Information query
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