Invention Grant
- Patent Title: Compositions and methods relating to hindering DOT1L recruitment by MLL-fusion proteins
-
Application No.: US14763596Application Date: 2014-02-14
-
Publication No.: US09862746B2Publication Date: 2018-01-09
- Inventor: Zaneta Nikolovska-Coleska , Chenxi Shen , Jay Hess
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, SC
- International Application: PCT/US2014/016377 WO 20140214
- International Announcement: WO2014/127191 WO 20140821
- Main IPC: A61K31/551
- IPC: A61K31/551 ; C07D243/10 ; A61K45/06 ; C07K7/06 ; G01N33/574 ; C07K14/82 ; A61K31/352 ; A61K31/437 ; A61K31/4402 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/5513 ; A61K38/08 ; C07D213/74 ; C07D261/20 ; C07D311/76 ; C07D405/04 ; C07D409/04 ; C07D519/00
Abstract:
The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.
Public/Granted literature
- US20150368300A1 COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS Public/Granted day:2015-12-24
Information query
