A resistive microelectronic fluid sensor implemented as an integrated voltage divider circuit can sense the presence of a fluid within a fluid reservoir, identify the fluid, and monitor fluid temperature or volume. Such a sensor has biomedical, industrial, and consumer product applications. After fluid detection, the fluid can be expelled from the reservoir and replenished with a fresh supply of fluid. A depression at the bottom of the sample reservoir allows a residual fluid to remain undetected so as not to skew the measurements. Electrodes can sense variations in the resistivity of the fluid, indicating a change in the fluid chemical composition, volume, or temperature. Such fluctuations that can be electrically sensed by the voltage divider circuit can be used as a thermal actuator to trigger ejection of all or part of the fluid sample.