An electronic device and a power protection method are provided. The electronic device includes a transfer port, a switch, a first detecting unit and a second detecting unit. The transfer port provides a driving voltage to an external device. The switch is coupled between the transfer port and a supply power source, and the switch is selectively turned off according to at least one of a first control signal and a second control signal. The first detecting unit generates the first control signal when a voltage drop of the driving voltage exceeds a threshold voltage. The second detecting unit generates a sampling voltage by detecting the driving voltage and generates the second control signal when the sampling voltage is lower than a first reference voltage. The electronic device can provide a power protection when an external device is plugged in/out the transfer port.