A method of descaling a water dispensing system included in a refrigerator appliance with a water dispenser is disclosed. The method of descaling includes the step of removing a water filter cartridge from a filter port of the refrigerator appliance wherein the filter port is in fluid communication with the water dispenser. The method also includes the step of inserting a descaling cartridge containing descaling fluid into the filter port of the refrigerator appliance. The method further includes the step of advancing the descaling fluid from the descaling cartridge through the water dispenser.