Methods of operating a system on chip including a first power domain and a second power domain are provided. The method includes measuring at least one of a voltage and a current, which are applied to the first power domain in analog mode to obtain a measurement result; calculating a first power consumed in the first power domain based on the measurement result; calculating a second power consumed in the second power domain in digital mode based on an activity of the second power domain; and controlling a total power of the system on chip based on the first power and the second power. At least one of the measuring, calculating a first power, calculating a second power and controlling are performed by at least one processor.