Invention Grant
- Patent Title: Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
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Application No.: US15399562Application Date: 2017-01-05
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Publication No.: US09931317B2Publication Date: 2018-04-03
- Inventor: Heather Elizabeth Burks , Michael A. Dechantsreiter , Guo He , Jill Nunez , Stefan Peukert , Clayton Springer , Yingchuan Sun , Noel Marie-France Thomsen , George Scott Tria , Bing Yu
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Main IPC: A61K31/381
- IPC: A61K31/381 ; C07D333/64 ; A61K31/4196 ; A61K31/422 ; A61K31/4245 ; A61K31/4436 ; A61K31/506 ; A61K45/06 ; C07D333/66 ; C07D409/12 ; C07D413/04 ; C07D413/12 ; C07D409/04 ; C07D409/10 ; C07D417/12 ; A61K31/397 ; A61K31/4025 ; A61K31/404 ; A61K31/41 ; A61K31/428 ; A61K31/5377 ; A61K31/4745
Abstract:
The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
Public/Granted literature
- US20170112805A1 BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS Public/Granted day:2017-04-27
Information query
