Invention Grant
- Patent Title: Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
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Application No.: US14913366Application Date: 2014-08-27
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Publication No.: US09938316B2Publication Date: 2018-04-10
- Inventor: Steven J. D. Karlish , Adriana Katz , Daniel M. Tal , Arie Marcovich
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2014/050773 WO 20140827
- International Announcement: WO2015/029035 WO 20150305
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J19/00
Abstract:
The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.
Public/Granted literature
- US20160244479A1 SELECTIVE INHIBITORS OF ALPHA2 ISOFORM OF Na,K-ATPase AND USE FOR REDUCTION OF INTRA-OCULAR PRESSURE Public/Granted day:2016-08-25
Information query
